Yes, it’s definitely possible, but…
I started drawing on an iPad a while ago (with Procreate), and that took some getting used to.
At first, I started drowning in all the technical and creative possibilities.
After a few months of practice I now feel that I am starting to find a good mode. And I’m really enjoying all the pencils, brushes, chalks, reeds, charcoals etc. etc. etc. Instead of getting paralyzed by alllll of those choices.
Apparently, it takes a tiny creative crisis to get a step further in my creative process.
Luckily, the crisis itself can also be a subject for a drawing.
(turtles all the way down)